Eric Feyfant

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang, Bradford Graves, Vincent Guerlavais et al. · Proceedings of the National Academy of Sciences · 2013 · 661 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

A general approach to site-specific antibody drug conjugates

Feng Tian, Yingchun Lu, Anthony Manibusan et al. · Proceedings of the National Academy of Sciences · 2014 · 317 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline

Matthew W. Olson, Alexey Ruzin, Eric Feyfant et al. · Antimicrobial Agents and Chemotherapy · 2006 · 201 citations · Full text

Life Sciences, Biochemistry, Microbiology +15

Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development

Vincent Guerlavais, Tomi K. Sawyer, Luis A. Carvajal et al. · Journal of Medicinal Chemistry · 2023 · 125 citations · Full text

Medicine, Oncology, Pharmacology +14

Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations

Thomas Steinbrecher, Chongkai Zhu, Lingle Wang et al. · Journal of Molecular Biology · 2016 · 115 citations

Life Sciences, Biochemistry, Molecular Biology +16