Eric Feyfant

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang, Bradford Graves, Vincent Guerlavais et al. · Proceedings of the National Academy of Sciences · 2013 · 653 citations · Full text

A general approach to site-specific antibody drug conjugates

Feng Tian, Yingchun Lu, Anthony Manibusan et al. · Proceedings of the National Academy of Sciences · 2014 · 309 citations · Full text

Medicinal Chemistry, Biochemistry, Polymer-drug Conjugate +15

Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline

Matthew W. Olson, Alexey Ruzin, Eric Feyfant et al. · Antimicrobial Agents and Chemotherapy · 2006 · 200 citations · Full text

Microbial Pathogens, Antibacterial Activity, Antimicrobial Chemotherapy +18

Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations

Thomas Steinbrecher, Chongkai Zhu, Lingle Wang et al. · Journal of Molecular Biology · 2016 · 113 citations

Protein Chemistry, Biochemistry, Protein Folding +8

Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development

Vincent Guerlavais, Tomi K. Sawyer, Luis A. Carvajal et al. · Journal of Medicinal Chemistry · 2023 · 110 citations · Full text