Functional classification of memory CD8+ T cells by CX3CR1 expression

Jan P. Böttcher, Marc Beyer, Felix Meissner, +19

Nature Communications

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

Tobias Baumann, Andreas Dunkel, Christian Schmid, +34

Nature Immunology

T-regulatory CellImmunologyImmune RegulationCellular PhysiologyRegulatory Myeloid Cells +10

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

Detian Yuan, Shan Huang, Emanuel Berger, +40

Cancer Cell

Chronic Mitochondrial DysfunctionMitochondrial FunctionBiliary CancerLiver PhysiologyImmunology +7

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

Felix Bayerl, Philippa Meiser, Sainitin Donakonda, +24

Immunity

Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion

Bastian Höchst, Frank A. Schildberg, Pia Sauerborn, +11

Journal of Hepatology

InflammationCytokinePeripheral Blood MonocytesLiver PhysiologyMedicine +8

Low-dose Cyclophosphamide Treatment Impairs Regulatory T Cells and Unmasks AFP-specific CD4+ T-cell Responses in Patients With Advanced HCC

Tim F. Greten, Lars A. Ormandy, Annika Fikuart, +5

Journal of Immunotherapy

Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver

Barbara T. Grünwald, Veronika Harant, Susanne Schaten, +16

Gastroenterology

Premetastatic NichePancreatic CancerHepatologyLiver PhysiologyHistopathology +8

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

Benjamin Knier, Michael Hiltensperger, Christopher Sie, +14

Nature Immunology

Autoimmune DiseaseAutoantibody ProductionMedicineImmunologyAutoimmunity +7

Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity

Jan P. Böttcher, Oliver Schanz, Dirk Wohlleber, +17

Cell Reports

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice

Bastian Höchst, Frank A. Schildberg, Jan P. Böttcher, +10

Hepatology