Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Michael Dudek, Dominik Pfister, Sainitin Donakonda, +45

Nature

Autoimmune DiseaseHepatologyImmune PathologyLiver PhysiologyT-regulatory Cell +10

A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

Philippa Meiser, Moritz Knolle, Anna Hirschberger, +20

Cancer Cell

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

Felix Bayerl, Philippa Meiser, Sainitin Donakonda, +24

Immunity

PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells

Sebastian Lacher, Janina Dörr, Gustavo P. de Almeida, +26

Nature

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Sophie Flommersfeld, Jan P. Böttcher, Jonatan Ersching, +17

Immunity

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

Simon Zenke, Margriet M. Palm, Julia Braun, +10

Immunity

Ctla-4 Confers RobustnessSignal TransductionReceptors Cd28MedicineCell Interaction +7

Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation

Kira L. Diehl, Julia Vorac, Kristina Hofmann, +6

Cells

ImmunologyHigh-fat DietFatty Liver DiseaseInflammationMetabolic Syndrome +17

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Míriam Díez Bosch, Nina Kallin, Sainitin Donakonda, +53

Nature

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods

Felix Bayerl, David Alejandro Bejarano, Giulia Bertacchi, +16

European Journal of Immunology

EngineeringMicroscopyDc SubsetsImmunologyBiomedical Engineering +18

Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells

Adriana M. Mujal, Mark Owyong, Endi K. Santosa, +9

Immunity