Elena C. Leon

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

David Calabrese, Xiang Chen, Elena C. Leon et al. · Nature Communications · 2018 · 167 citations · Full text

Medicine, Molecular Biology, Oncology +16

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

Kenneth M. Felsenstein, Lindsey B. Saunders, John K. Simmons et al. · ACS Chemical Biology · 2015 · 125 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation

John K. Simmons, Aleksandra M. Michalowski, Benjamin J. Gamache et al. · Molecular Cancer Therapeutics · 2017 · 34 citations · Full text

Medicine, Oncology, Pharmacology +17

AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models

Amara Greer-Short, Anna Greenwood, Elena C. Leon et al. · Nature Communications · 2025 · 34 citations · Full text

Medicine, Cardiology, Molecular Genetics +12

Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus

Huanyu Zhou, Jin Ye Yang, Chetan Srinath et al. · Circulation · 2023 · 16 citations

Life Sciences, Biotechnology, Cardiology +15