Roger R. Hinshaw

Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Steve R. Turner, Joseph W. Strohbach, Rubén Tommasi et al. · Journal of Medicinal Chemistry · 1998 · 293 citations · Full text

Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor

Susan M. Poppe, Dea Slade, K. T. Chong et al. · Antimicrobial Agents and Chemotherapy · 1997 · 121 citations · Full text

Dihydropyrone Pnu-140690, Immunology, Pharmacotherapy +17

Structure-Based Design of HIV Protease Inhibitors:  Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Suvit Thaisrivongs, Harvey I. Skulnick, Steve R. Turner et al. · Journal of Medicinal Chemistry · 1996 · 96 citations · Full text

Hiv Protease Inhibitors, Pharmacotherapy, Antiviral Drug +20

Structure-Based Design of Novel HIV Protease Inhibitors:  Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Suvit Thaisrivongs, Musiri N. Janakiraman, Kong-Teck Chong et al. · Journal of Medicinal Chemistry · 1996 · 88 citations

Hiv Protease Inhibitors, Peptide Science, Antiviral Drug +17

Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

Suvit Thaisrivongs, Donna L. Romero, Rubén Tommasi et al. · Journal of Medicinal Chemistry · 1996 · 86 citations · Full text

Crystal Structure, Bioorganic Chemistry, Antiviral Drug +17