Hatsuo Kawada

Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)

Kazutomo Kinoshita, Kohsuke Asoh, Noriyuki Furuichi et al. · Bioorganic & Medicinal Chemistry · 2011 · 163 citations · Full text

Chemoprevention Strategy, Medicine, Anti-cancer Agent +3

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

Mikimasa Tanada, Minoru Tamiya, Atsushi Matsuo et al. · Journal of the American Chemical Society · 2023 · 132 citations

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Atsushi Ohta, Mikimasa Tanada, Shojiro Shinohara et al. · Journal of the American Chemical Society · 2023 · 86 citations

9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5<i>H</i>-benzo[<i>b</i>]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors

Kazutomo Kinoshita, Takamitsu Kobayashi, Kohsuke Asoh et al. · Journal of Medicinal Chemistry · 2011 · 83 citations · Full text

Compound 13D, Molecular Pharmacology, Medicinal Chemistry +12

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799

Jun Ohwada, Hirosato Ebiike, Hatsuo Kawada et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 70 citations · Full text

Biological Activity, Biochemistry, Natural Sciences +10