João Nunes

Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition

Samuel E. Dalton, Lars Dittus, Daniel A. Thomas et al. · Journal of the American Chemical Society · 2017 · 112 citations

Drug Target, Molecular Biology, General Approach +23

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Robert P. Law, João Nunes, Chun‐wa Chung et al. · Angewandte Chemie International Edition · 2021 · 112 citations

Fak Inhibitors, Molecular Biology, Degradation Reaction +17

Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation

Filipa G. Pinho, Adam E. Frampton, João Nunes et al. · Cancer Research · 2013 · 90 citations · Full text

Breast Oncology, Cancer Biology, Mammary Gland Development +17

Sphingosine kinase 1 inhibition sensitizes hormone‐resistant prostate cancer to docetaxel

Lysann Sauer, João Nunes, Vishal A. Salunkhe et al. · International Journal of Cancer · 2009 · 55 citations · Full text

LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer

Yichen Xu, Hua Zhang, Van T.M. Nguyen et al. · Cell Reports · 2015 · 30 citations · Full text

Scaffolding Function, Cancer Biology, Epigenetics +21