Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

Yoon-Mi Lee, Gibok Lee, Taek-In Oh, +6

International Journal of Oncology

Chemoprevention StrategyApoptosisCell DeathOxidative StressAnti-cancer Agent +16

Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation

Jiwon Han, Do-Wan Shim, Woo-Young Shin, +6

International Journal of Molecular Sciences

Inflammatory Lung DiseaseLung InflammationAnti-inflammatory EffectImmunologyImmune Regulation +23

BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination

Do-Wan Shim, Woo-young Shin, Sang-Hyeun Yu, +6

Scientific Reports

Nlrp3 AlkylationMolecular RegulationImmunologyCell DeathNlrp3 Inhibitor +15

Anti-inflammatory and anti-allergic effects of Agrimonia pilosa Ledeb extract on murine cell lines and OVA-induced airway inflammation

Jae‐Jin Kim, Jun Jiang, Do-Wan Shim, +9

Journal of Ethnopharmacology

InflammationAsthmaOva-induced Airway InflammationAnti-allergic EffectsAllergy +8

Anti-Inflammatory Action of an Antimicrobial Model Peptide That Suppresses the TRIF-Dependent Signaling Pathway via Inhibition of Toll-Like Receptor 4 Endocytosis in Lipopolysaccharide-Stimulated Macrophages

Do-Wan Shim, Kang-Hyuck Heo, Youngkyu Kim, +9

PLoS ONE

Host Defense PeptidesMicrobial PathogensInnate Immune SystemImmunologyAntimicrobial Peptides +21

Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner

Eunji Gim, Do-Wan Shim, Inhwa Hwang, +2

Immune Network

Innate Immune SystemViral PathogenesisImmunologyImmune RegulationInnate Immunity +20

Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic responses via attenuation of inflammasome activation in experimental models

Woo-Young Shin, Do-Wan Shim, Myong-Ki Kim, +7

Journal of Ethnopharmacology

InflammationAnti-inflammatoryInflammasome ActivationImmunologyCinnamomum Cassia +6

A novel synthetic derivative of melatonin, 5-hydroxy-2’-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation

Do-Wan Shim, Hee Jae Shin, Jiwon Han, +5

Toxicology and Applied Pharmacology

InflammationAnti-inflammatoryOxysterolBiochemistryInflammasome Activation +9

<i>Cichorium intybus</i> Linn. Extract Prevents Type 2 Diabetes Through Inhibition of NLRP3 Inflammasome Activation

Do-Wan Shim, Jiwon Han, Young-Eun Ji, +7

Journal of Medicinal Food

ImmunologyImmune RegulationInsulin SignalingInflammationMetabolic Syndrome +16

Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation

Seunghwan Son, Do-Wan Shim, Inhwa Hwang, +2

Frontiers in Immunology