Yagmur U. Doruk

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

Stefan Gahbauer, G.J. Correy, M. Schuller et al. · Proceedings of the National Academy of Sciences · 2023 · 117 citations · Full text

Drug Target, Protein Assembly, Biomolecular Structure Prediction +17

A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude

Yagmur U. Doruk, Darya Yarparvar, Yasemin Kübra Akyel et al. · Journal of Biological Chemistry · 2020 · 78 citations · Full text

Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2

Patrick C. O’Leary, Huadong Chen, Yagmur U. Doruk et al. · Cancer Research · 2022 · 26 citations · Full text

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2

Stefan Gahbauer, G.J. Correy, M. Schuller et al. · 2022 · 15 citations · Full text

Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning

G.J. Correy, Moira Rachman, Takaya Togo et al. · Science Advances · 2025 · 14 citations · Full text