Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation

An-Hsun Chou, Tu‐Hsueh Yeh, Pin Ouyang, +3

Neurobiology of Disease

Knockout MouseNeurodegenerative DiseasesSca3 Transgenic MiceMolecular NeuroscienceDevelopmental Biology +6

PINK1 mutants associated with recessive Parkinson’s disease are defective in inhibiting mitochondrial release of cytochrome c

Hung‐Li Wang, An-Hsun Chou, Tu‐Hsueh Yeh, +5

Neurobiology of Disease

Mitochondrial ReleaseNeurodegenerative DiseasesBiochemistryMitochondrial FunctionPink1 Mutants +6

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

Jun-Shiao Chou, Chuyu Chen, Ying‐Ling Chen, +5

Neurobiology of Disease

Pd Transgenic MouseMolecular NeuroscienceSnpc Dopaminergic NeuronsPsychiatryEarly-phase Dysfunction +9

Heterodimerization of opioid receptor‐like 1 and µ‐opioid receptors impairs the potency of µ receptor agonist

Hung‐Li Wang, Chia‐Yu Hsu, Pei‐Chen Huang, +5

Journal of Neurochemistry

TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1

Pritha Majumder, Yi‐Ting Chen, Jayarama Krishnan Bose, +8

Acta Neuropathologica

ChromatinTranscriptional RegulationDevelopmental BiologySignal TransductionCell Regulation +9

Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

Ching‐Chi Chiu, Tu-Hsueh Yeh, Rou-Shayn Chen, +13

Frontiers in Cellular Neuroscience

Microrna-204-5p LeadsApoptosisCell DeathPathologyEr Stress +20

PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway

Ching‐Chi Chiu, Tu‐Hsueh Yeh, Chin-Song Lu, +12

Oncotarget

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model

Ching‐Chi Chiu, Chin-Song Lu, Yi‐Hsin Weng, +13

Molecular Neurobiology

MitophagyKnockin Mouse ModelMitochondrial FunctionMitochondrial DysfunctionGenetics +8

Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models

Yu-Chuan Liu, Hung‐Li Wang, Ying‐Zu Huang, +11

Biochemical Pharmacology

MechanobiologyMedicinePhysiologyMouse ModelsAchilles Tendinopathy +6

T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse

An-Hsun Chou, Ying‐Ling Chen, Ching‐Chi Chiu, +6

Neuropharmacology

Knockout MouseNeurodegenerative DiseasesAtaxic SymptomAutoimmune DiseaseMedicine +8