Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

Ralda Nehme, Emanuela Zuccaro, Sulagna Ghosh, +18

Cell Reports

:Gfp Reporter GeneDevelopmental Cognitive NeuroscienceSynaptic TransmissionNeurotransmitterNmdar-mediated Synaptic Transmission +18

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

Jon M. Madison, Fangjian Zhou, Aparna Nigam, +22

Molecular Psychiatry

Mrna Expression AbnormalitiesEmbryonic Stem CellInduced Pluripotent Stem CellDevelopmental BiologyMedicine +10

Early Alzheimer’s disease pathology in human cortex involves transient cell states

Vahid Gazestani, Tushar Kamath, Naeem Nadaf, +21

Cell

Neurodegenerative DiseasesHuman CortexAlzheimer's DiseaseDisease PathologyTransient Cell States +7

Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages

Michael F. Wells, James Nemesh, Sulagna Ghosh, +24

Cell stem cell

Natural VariationGeneticsViral PathogenesisGenetic EpidemiologyDisease Gene Identification +20

Mapping genetic effects on cellular phenotypes with “cell villages”

Jana M. Mitchell, James Nemesh, Sulagna Ghosh, +11

Genetic AnalysisGenotype-phenotype AssociationMedicineGeneticsSmn Protein +12

Brain Chimeroids reveal individual susceptibility to neurotoxic triggers

Noelia Antón-Bolaños, Irene Faravelli, Tyler Faits, +12

Nature

NeuropsychologyBrain ChimeroidsPsychopharmacologyNeurologyNeuroscience +1

Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development

Donna L. McPhie, Ralda Nehme, Caitlin Ravichandran, +11

Translational Psychiatry

Greater genetic diversity is needed in human pluripotent stem cell models

Sulagna Ghosh, Ralda Nehme, Lindy E. Barrett

Nature Communications

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Ralda Nehme, Olli Pietiläinen, Mykyta Artomov, +42

Nature Communications

Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

Aiping Jiang, Serwah Danquah, Vera Valakh, +7

Cell