David Cousin

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Tom D. Heightman, Valério Berdini, Hannah Braithwaite et al. · Journal of Medicinal Chemistry · 2018 · 63 citations · Full text

Multiple Cancers, Tumor Biology, Medicinal Chemistry +22

A new approach to combretastatin D₂

David Cousin, John Mann, M. Nieuwenhuyzen et al. · Organic & Biomolecular Chemistry · 2005 · 20 citations

Chromatin, Preliminary Biological Data, Convergent Route +15

Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines

David Cousin, Jihong Zhang, Marc Hummersone et al. · MedChemComm · 2016 · 19 citations · Full text

Neuro-oncology, Medicinal Chemistry, Glioma +15

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Tom D. Heightman, Valério Berdini, Luke Bevan et al. · Journal of Medicinal Chemistry · 2021 · 17 citations · Full text

[Thermosensitive mutants of K12 Escherichia coli. 3. A lethal mutation of E. coli affecting the activity of the adenylate kinase].

David Cousin, G. Buttin · PubMed · 1969 · 12 citations