Characterization of a new continuous cell line derived from a human retinoblastoma.

Rosemary C. McFall, Theodore W. Sery, Marcia Makadon

PubMed

Retinal BiologyRetinaOphthalmologyCell DivisionHuman Retinoblastoma +10

Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator inhibitor-1 synthesis in vascular smooth muscle cells

Christopher Reilly, Rosemary C. McFall

Journal of Biological Chemistry

EngineeringTotal RnaGrowth Factor-betaCytoskeletonBiomedical Engineering +19

Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors

Mark E. Fraley, William F. Hoffman, Robert S. Rubino, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryKdr Kinase InhibitorsInitial Sar StudiesMedicine +8

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

Mark E. Fraley, Robert S. Rubino, William F. Hoffman, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryKdr Kinase InhibitorsCellular ActivityMedicine +10

Effects of Subtype-Selective and Balanced Angiotensin II Receptor Antagonists in a Porcine Coronary Artery Model of Vascular Restenosis

William R. Huckle, Marlene Drag, Wayne R. Acker, +13

Circulation

Potent <i>N</i>-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Mark T. Bilodeau, Adrienne E. Balitza, Timothy J. Koester, +21

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyMolecular PharmacologyMedicinal ChemistryVivo Potency +18

The WIRL-3 rat liver cell lines and their transformed derivatives.

Leila Diamond, Rosemary C. McFall, Yutaka Tashiro, +1

PubMed

Epithelial Cell LinesWeanling RatPathologyCell CultureTransformed Derivatives +20

Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors

Mark E. Fraley, Kenneth L. Arrington, Carolyn A. Buser, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceIndolyl Quinolinone ClassBiochemistryMedicine +10

The effects of two isomeric benzoflavones on aryl hydrocarbon hydroxylase and the toxicity and carcinogenicity of polycyclic hydrocarbons.

Leila Diamond, Rosemary C. McFall, J. A. Miller, +1

PubMed

Hamster Embryo CellsOrganic ChemistryIsomer 5,6-BenzoflavoneToxicological MechanismOxidative Stress +15

The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase

Mark T. Bilodeau, Leonard D. Rodman, Georgia B. McGaughey, +9

Bioorganic & Medicinal Chemistry Letters

Kdr KinaseMedicinal ChemistryBiochemistryMedicineNatural Sciences +8