Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Wai‐Ching Hon, Michael Wilson, Karl Harlos, +7

Nature

Protein ChemistryProteinlipid InteractionMolecular CharacterizationProtein FunctionBiochemistry +7

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

Heather Lang, Helle J. Jacobsen, Shinji Ikemizu, +11

Nature Immunology

Tcr Cross-reactivityNeurological DisorderMedicineNeurological FunctionImmune Regulation +10

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Peter L. Roach, I.J. Clifton, Vilmos Fülöp, +6

Nature

Crystal StructureBiochemistryIsopenicillin N SynthaseBiocatalysisNatural Sciences +6

Tick Histamine-Binding Proteins

Guido C. Paesen, Peter L. Adams, Karl Harlos, +1

Molecular Cell

Protein FunctionSignal TransductionMolecular BiologyTick Histamine-binding ProteinsImmunoglobulin E +1

Initiation of T cell signaling by CD45 segregation at 'close contacts'

Veronica T. Chang, Ricardo A. Fernandes, Kristina A. Ganzinger, +14

Nature Immunology

Signal TransductionCell SignalingCd45 SegregationT-regulatory CellImmunology +7

Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

E. Yvonne Jones, Simon J. Davis, Karl Harlos, +1

Nature

Crystal StructureSoluble FormBiophysicsCell AdhesionProtein X-ray Crystallography +10

Structural basis of substrate discrimination and integrin binding by autotaxin

Jens Hausmann, Satwik Kamtekar, Evangelos Christodoulou, +21

Nature Structural & Molecular Biology

Protein FunctionSignal TransductionProtein AssemblyBiochemistryProtein Folding +7

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.

Karl Harlos, Christopher J. Schofield, Zhihong Zhang, +3

Nature Structural Biology

BiochemistryNatural SciencesBiocatalysisEnzyme CatalysisMolecular Biology +2

Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains

Stephan D. Gadola, Nathan R. Zaccai, Karl Harlos, +6

Nature Immunology

Protein AssemblyMedicineNatural SciencesReceptor (Biochemistry)Molecular Biology +8

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

Thomas S. Walter, Jonathan M. Diprose, Chris Mayo, +15

Acta Crystallographica Section D Biological Crystallography

X-ray CrystallographyEngineeringMicroscopyCrystal Growth TechnologyMolecular Biology +21