A functional and structural basis for TCR cross-reactivity in multiple sclerosis

Heather Lang, Helle J. Jacobsen, Shinji Ikemizu, +11

Nature Immunology

Tcr Cross-reactivityNeurological DisorderMedicineNeurological FunctionImmune Regulation +10

Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy

Mikkel W. Pedersen, Helle J. Jacobsen, Klaus Koefoed, +4

Cancer Research

Anti-egfr Monoclonal AntibodiesEgfr InternalizationImmunologySuperior Anticancer EfficacyImmune Checkpoint Inhibitor +10

Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice

Ellen Andersson, Bjarke Endel Hansen, Helle J. Jacobsen, +9

Proceedings of the National Academy of Sciences

Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor

Klaus Koefoed, Lucilla Steinaa, Josefine Nielsen Søderberg, +8

mAbs

Immunocytochemical TechniqueHuman GrowthImmunologyPathologyRational Identification +19

Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Helle J. Jacobsen, Thomas T. Poulsen, Anna Dahlman, +10

Clinical Cancer Research

Myelin oligodendrocyte glycoprotein‐35–55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA‐DR2‐transgenic mice

Cathleen Rich, Jason M. Link, Alex Zamora, +7

European Journal of Immunology

Immune RegulationImmunologyPathologyAntigen ProcessingImmunotherapy +16

Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance

Mikkel W. Pedersen, Helle J. Jacobsen, Klaus Koefoed, +8

Molecular Cancer Therapeutics

Sym015: A Highly Efficacious Antibody Mixture against <i>MET</i> -Amplified Tumors

Thomas T. Poulsen, Michael M. Grandal, Niels Jørgen Østergaard Skartved, +14

Clinical Cancer Research

Preclinical Pharmacokinetics and Safety of Sym004: A Synergistic Antibody Mixture Directed against Epidermal Growth Factor Receptor

Niels Jørgen Østergaard Skartved, Helle J. Jacobsen, Mikkel W. Pedersen, +5

Clinical Cancer Research

Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms

Michael M. Grandal, Serhiy Havrylov, Thomas T. Poulsen, +15

Molecular Cancer Therapeutics