Yongchang Yan

Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Liang Chen, Biyun Zhu, Gaomeng Ru et al. · Nature Biotechnology · 2022 · 156 citations

Life Sciences, Genetics, Molecular Biology +14

Mitochondrial base editor induces substantial nuclear off-target mutations

Zhi‐Xin Lei, Haowei Meng, Lulu Liu et al. · Nature · 2022 · 120 citations

Life Sciences, Genetics, Molecular Biology +13

Increasing the efficiency and precision of prime editing with guide RNA pairs

Yuan Zhuang, Jiangle Liu, Hao Wu et al. · Nature Chemical Biology · 2021 · 108 citations

Life Sciences, Genetics, Molecular Biology +11

Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors

Zhi‐Xin Lei, Haowei Meng, Zhicong Lv et al. · Nature Methods · 2021 · 59 citations

Life Sciences, Genetics, Molecular Biology +8

DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes

Menghao Liu, Jun Zhang, Chenxu Zhu et al. · Nature Communications · 2021 · 19 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15