Alexander S. Kane

Novel Selective Allosteric Activator of the M₁Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats

Carrie K. Jones, Ashley E. Brady, Albert A. Davis et al. · Journal of Neuroscience · 2008 · 244 citations · Full text

Medicine, Neuroscience, Pharmacology +16

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Alice L. Rodriguez, Mark D. Grier, Carrie K. Jones et al. · Molecular Pharmacology · 2010 · 179 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

Douglas J. Sheffler, Richard D. Williams, Thomas M. Bridges et al. · Molecular Pharmacology · 2009 · 133 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M₁ Receptor Function in the Central Nervous System

Evan P. Lebois, Thomas M. Bridges, L. Michelle Lewis et al. · ACS Chemical Neuroscience · 2009 · 100 citations

Medicine, Neuroscience, Pharmacology +17

Discovery of 2‐(2‐Benzoxazoyl amino)‐4‐Aryl‐5‐Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu₅): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

Ralf Mueller, Eric S. Dawson, Jens Meiler et al. · ChemMedChem · 2012 · 45 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11