Development of Pd/C-Catalyzed Cyanation of Aryl Halides

Hannah Yu, Rachel N. Richey, William Miller, +2

The Journal of Organic Chemistry

Chemical EngineeringCross-coupling ReactionEngineeringAryl BromidePalladium-catalyzed Cyanation +8

Rapid Development and Scale-Up of a 1<i>H</i>-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Scott A. May, Martin D. Johnson, Timothy M. Braden, +10

Organic Process Research & Development

Challenging Cyclization ReactionCombinatorial ChemistryChemical EngineeringNovel OrganocatalystsEngineering +11

Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing

Michael O. Frederick, Raymond A. Boyse, Timothy M. Braden, +29

Organic Process Research & Development

Purification MethodChemical EngineeringEngineeringIndustrial EngineeringPeptide Engineering +13

Cyclocarbopalladation of Alkynes:  A Stereoselective Method for Preparing Dibenzoxapine Containing Tetrasubstituted Exocyclic Alkenes

Hannah Yu, Rachel N. Richey, Matthew W. Carson, +1

Organic Letters

EngineeringOrganic ChemistryChemistryHeterocycle ChemistryStereoselective Synthesis +14

(<i>S</i>)-<i>N</i>-{3-[1-Cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1<i>H</i>-indol-7-yl}-methanesulfonamide: A Potent, Nonsteroidal, Functional Antagonist of the Mineralocorticoid Receptor

Michael G. Bell, Douglas L. Gernert, Timothy A. Grese, +14

Journal of Medicinal Chemistry

HypertensionFunctional AntagonistPharmacotherapyChemical BiologyIndole Analogs +14

Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization

Marvin M. Hansen, Daniel J. Jarmer, Enver Arslantas, +19

Organic Process Research & Development

Reactive CrystallizationBioorganic ChemistryOrganic ChemistryPeptide ScienceChemistry +17

Development of a Leuckart–Wallach Reaction in Flow for the Synthesis of Abemaciclib

Michael O. Frederick, Mark A. Pietz, Douglas P. Kjell, +6

Organic Process Research & Development

Chemical EngineeringKey Building BlockEngineeringReaction EngineeringLeuckart–wallach Reaction +7

Double Heck Route to a Dibenzoxepine and Convergent Suzuki Cross-Coupling Strategy for the Synthesis of an MR Antagonist

Marvin M. Hansen, Neil J. Kallman, Thomas M. Koenig, +7

Organic Process Research & Development

Combinatorial ChemistryMr Antagonist Ly2623091Organic ChemistryChemistryDiversity Oriented Synthesis +15

Development of an Efficient Palladium-Catalyzed Intramolecular Carbometalation Reaction for the Synthesis of a Dibenzoxapine Containing Tetra-substituted Exocyclic Alkene

Rachel N. Richey, Hannah Yu

Organic Process Research & Development

Target CompoundOrganic ChemistryPeptide ScienceChemistryMedicinal Chemistry +15

Mitigating the Risk of Coprecipitation of Pinacol during Isolation from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Boron Pinacol Esters: Use of Modeling for Process Design

Jeremy M. Merritt, Marimuthu Andiappan, Mark A. Pietz, +3

Organic Process Research & Development

Process DesignEngineeringTelescoped Miyaura BorylationProcess DefinitionHigh Purity +4