Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

María Casanova-Acebes, Erica Dalla, Andrew M. Leader, +24

Nature

InflammationMedicineImmunologyTumor ImmunityPathology +8

Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Assaf Magen, Pauline Hamon, Nathalie Fiaschi, +50

Nature Medicine

Cancer ImmunosurveillancePd-1 BlockadeImmunologyTumor ImmunityImmune Checkpoint Inhibitor +9

Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

Andrew M. Leader, John A. Grout, Bárbara Maier, +30

Cancer Cell

Cancer DetectionTumor HeterogeneityMedicineTumor ClassificationPatient Stratification +11

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer

Matthew D. Park, Ivan Reyes-Torres, Jessica LeBérichel, +30

Nature Immunology

Lung InflammationMedicineImmunologyCell DeathNk Cell Paucity +6

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis

Nelson M. LaMarche, Samarth Hegde, Matthew D. Park, +35

Nature

InflammationHematological MalignancyMalignant Blood DisorderHematologyImmunology +8

A shift in lung macrophage composition is associated with COVID-19 severity and recovery

Steven T. Chen, Matthew D. Park, Diane M. Del Valle, +28

Science Translational Medicine

Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis

Matthew D. Park, Jessica Le Bérichel, Pauline Hamon, +36

Science

Ovarian cancer-derived IL-4 promotes immunotherapy resistance

Gürkan Mollaoglu, Alexander Tepper, Chiara Falcomatà, +16

Cell

Cancer ImmunosurveillanceImmunologyImmune Checkpoint InhibitorImmunotherapyMedicine +1

Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis

Erica Dalla, Michael Papanicolaou, Matthew D. Park, +10

Cell

Breast Cancer MetastasisBreast OncologyOncologyLung InflammationMedicine +7

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

C. Matthias Wilk, Flurin Cathomas, Orsolya Török, +27

Immunity

Neurodegenerative DiseasesMedicineImmunologyHematologyBrain-immune Interaction +11