Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

Kenji Maeda, Hirotomo Nakata, Yasuhiro Koh, +9

Journal of Virology

MedicineHuman RetrovirusImmunologyAntiviral ResponseAntiviral Drug Development +11

Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5

Kenji Maeda, Kazuhisa Yoshimura, Shiro Shibayama, +7

Journal of Biological Chemistry

The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31)

Kenji Sagawa, Teruaki Kimura, Mark Swieter, +1

Journal of Biological Chemistry

Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists

Hiromu Habashita, Masaya Kokubo, Shin-ichi Hamano, +8

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetPharmacotherapyChemical BiologyPharmaceutical Chemistry +16

Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31)

Kenji Sagawa, William D. Swaim, Juan Zhang, +2

Journal of Biological Chemistry

Design and Synthesis of a Highly Selective EP2-Receptor Agonist

Kousuke Tani, Atsushi Naganawa, Akiharu Ishida, +9

Bioorganic & Medicinal Chemistry Letters

Functional SelectivityMedicineReceptor (Biochemistry)Pharmacological AgentPharmacotherapy +2

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite

Rena Nishizawa, Toshihiko Nishiyama, Katsuya Hisaichi, +11

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesRational Drug DesignLead Identification +5

Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

Kousuke Tani, Atsushi Naganawa, Akiharu Ishida, +8

Bioorganic & Medicinal Chemistry

Molecular PharmacologyBiochemistryFunctional SelectivityMedicineG Protein-coupled Receptor +8

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists

Rena Nishizawa, Toshihiko Nishiyama, Katsuya Hisaichi, +11

Bioorganic & Medicinal Chemistry

Pharmaceutical SciencePharmacologyPharmacotherapyDrug DevelopmentMedicine +1

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles

Rena Nishizawa, Toshihiko Nishiyama, Katsuya Hisaichi, +11

Bioorganic & Medicinal Chemistry Letters

MedicineSpirodiketopiperazine-based Ccr5 AntagonistsClinical PharmacologyPharmacotherapyPharmacology +1