HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling

Brennan S. Dirk, Emily N. Pawlak, Aaron L. Johnson, +4

Scientific Reports

MIiSR: Molecular Interactions in Super-Resolution Imaging Enables the Analysis of Protein Interactions, Dynamics and Formation of Multi-protein Structures

Fabiana A. Caetano, Brennan S. Dirk, Joshua H. K. Tam, +7

PLoS Computational Biology

Protein AssemblyMolecular BiologyExtracellular MicrovesiclesCytoskeletonMolecular Interactions +18

The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells

Emily N. Pawlak, Brennan S. Dirk, Rajesh Abraham Jacob, +2

Retrovirology

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses

Jérémie Prévost, Suzanne Pickering, Mitchell J. Mumby, +15

mBio

The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis

Rajesh Abraham Jacob, Aaron L. Johnson, Emily N. Pawlak, +4

Virology

Autoimmune DiseaseMedicineHuman RetrovirusImmunologyAntiviral Response +5

Viral Bimolecular Fluorescence Complementation: A Novel Tool to Study Intracellular Vesicular Trafficking Pathways

Brennan S. Dirk, Rajesh Abraham Jacob, Aaron L. Johnson, +5

PLoS ONE

ImmunologyMolecular BiologyNovel ToolViral Structural ProteinAccessory Protein Nef +15

Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function

Amanda Evans, Jack Blackburn, Kyle Taruc, +6

Molecular Biology and Evolution

Viral PathogenesisImmunologySignaling PathwayReceptor Tyrosine KinaseCell Signaling +15

Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein

Cason R. King, Michael R. Cohen, Gregory J. Fonseca, +3

PLoS Pathogens

Viral ReplicationAdenovirus E1aViral Polymerase MechanismMolecular BiologyViral Structural Protein +17

A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression

Aaron L. Johnson, Brennan S. Dirk, Mathieu Coutu, +4

mSphere

DPX-Survivac, a novel T-cell immunotherapy, to induce robust T-cell responses in advanced ovarian cancer.

Oliver Dorigo, Stephan Fiset, Lisa D. MacDonald, +4

Journal of Clinical Oncology

ImmunologyImmunoeditingNovel T-cell ImmunotherapyImmunotherapeuticsImmune Cell Therapy +23