Barry Jones

The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data

R. Scott Obach, James G. Baxter, Theodore E. Liston et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 574 citations

Pharmacokinetic Modeling, Preclinical Drug Evaluation, Physiologically-based Pharmacokinetic Modeling +11

Reproducing human and cross-species drug toxicities using a Liver-Chip

Kyung‐Jin Jang, Monicah A. Otieno, Janey Ronxhi et al. · Science Translational Medicine · 2019 · 451 citations

Novel Approach To Predicting P450-Mediated Drug Metabolism:  Development of a Combined Protein and Pharmacophore Model for CYP2D6

Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne et al. · Journal of Medicinal Chemistry · 1999 · 160 citations

Systems Pharmacology, Medicinal Chemistry, Combined Protein +14

Identification of the cytochrome P450 enzymes involved in the <i>N</i>‐demethylation of sildenafil

Ruth Hyland, E. G. H. Roe, Barry Jones et al. · British Journal of Clinical Pharmacology · 2001 · 155 citations · Full text

A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6

Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne et al. · Journal of Medicinal Chemistry · 1999 · 128 citations

Drug Target, Novel Approach, Chemical Biology +19