Characterization of Novel Selective H₁-Antihistamines for Clinical Evaluation in the Treatment of Insomnia

Wilna J. Moree, Bin-Feng Li, Florence Jovic, +18

Journal of Medicinal Chemistry

Sleep DisordersIndene 1DPharmacotherapyMedicinal ChemistryPharmacological Study +14

Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction

Timothy D. Gross, Shine Chou, Daniel Bonneville, +9

Organic Process Research & Development

Chemical KineticsEngineeringChemical DevelopmentChemistryChemical Engineering +14

Studies on the structure–activity relationship of bicifadine analogs as monoamine transporter inhibitors

Mingzhu Zhang, Florence Jovic, Troy Vickers, +8

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipMolecular PharmacologyPharmaceutical ScienceMonoamine Transporter InhibitorsBiochemistry +8

Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors

Chen Chen, Brian Dyck, Beth A. Fleck, +8

Bioorganic & Medicinal Chemistry Letters

Monoamine Transporter InhibitorsPharmacological StudyBiochemistryMedicineMilnacipran Derivatives +6

Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors

Junko Tamiya, Brian Dyck, Mingzhu Zhang, +9

Bioorganic & Medicinal Chemistry Letters

Potent NorepinephrineBiochemistryMedicinePsychotropic MedicationMechanism Of Action +8

Novel benzothiophene H1-antihistamines for the treatment of insomnia

Wilna J. Moree, Florence Jovic, Timothy Coon, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistrySleepMedicinePharmacotherapyInsomnia +1

Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors

Troy Vickers, Brian Dyck, Junko Tamiya, +10

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical SciencePotent NorepinephrineBiochemistryMedicineHeteroaromatic Group +6

Immunologically driven antibodies chemical engineering: design and synthesis of a hapten aimed at nerve agent hydrolysis

Florence Jovic, Ludivine Louise, Charles Mioskowski, +1

Tetrahedron Letters

EngineeringBiochemistryNerve Agent HydrolysisNatural SciencesImmunoengineering +5

Characterization of Thien-2-yl 1<i>S</i>,2<i>R</i>-Milnacipran Analogues as Potent Norepinephrine/Serotonin Transporter Inhibitors for the Treatment of Neuropathic Pain

Brian Dyck, Junko Tamiya, Florence Jovic, +15

Journal of Medicinal Chemistry

Pain DisordersPain MedicineNeuropathic PainMolecular PainNet Ic50 +15

Synthesis of the Pleuromutilin Antibiotic SB-268091: A New Practical and Efficient Synthesis of Quinuclidine-4-thiol

Bernie M. Choudary, Robert G. Giles, Florence Jovic, +3

Organic Process Research & Development

Medicinal ChemistryPleuromutilin Antibiotic Sb-268091New PracticalMedicineQuinuclidine-4-thiol Ligand +7