Organic Process Research & Development · 2008 · 33 citations · 15 references
EngineeringChemical EngineeringChemistryIndustrial ChemistryReaction EngineeringReaction Process DesignReactor DesignReactor Scale-upBatch Reactor DesignBatch Reactor Scale-upChemical Process DevelopmentChemical Reagent DevelopmentFlow Chemistry
The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.
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Selective monolithiation of 2,5-dibromopyridine with butyllithium
Xin Wang, Philippe M. A. Rabbat, Paul O’Shea et al. · Tetrahedron Letters · 2000 · 78 citations