Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

Xiaoyang Lan, David J. Jörg, Florence M.G. Cavalli, +34

Nature

Neuro-oncologyEmbryonic Stem CellLineage PlasticityDevelopmental BiologyGlioma +9

Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

Laura M. Richards, Owen Whitley, Graham MacLeod, +34

Nature Cancer

Neuro-oncologyTranscriptional RegulationLineage PlasticityDevelopmental BiologyGlioma +8

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Brian Krug, Nicolas Jay, Ashot S. Harutyunyan, +25

Cancer Cell

Neuro-oncologyGliomaMedicineTherapeutic VulnerabilityNeurology +8

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Jonathon Torchia, Brian Golbourn, Shengrui Feng, +115

Cancer Cell

Tumor BiologyRadiation OncologyNeuro-oncologyOncologyEngineering +9

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

Nicole I. Park, Paul Guilhamon, Kinjal Desai, +24

Cell stem cell

ChromatinNeuro-oncologyGlioblastoma Stem CellsDevelopmental BiologyGlioma +11

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

Patty Sachamitr, Jolene Caifeng Ho, Felipe E. Ciamponi, +46

Nature Communications

Using high-density DNA methylation arrays to profile copy number alterations

Andrew Feber, Paul Guilhamon, Matthias Lechner, +8

Genome biology

Epigenetic ChangeGeneticsDna MethylationDna AnalysisMolecular Biology +21

Epigenetic Switch–Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer

Geneviève Deblois, Seyed Ali Madani Tonekaboni, Giacomo Grillo, +20

Cancer Discovery

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

Kulandaimanuvel Antony Michealraj, Sachin Kumar, Leo J.Y. Kim, +63

Cell

Epigenetic ChangeEpigenomicsPathologyMetabolic RegulationMedicine +1

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

Paul Guilhamon, Charles Chesnelong, Michelle Kushida, +25

eLife

High-grade GliomasChromatin AccessibilityGliomaCancer BiologyTumor Biology +17