DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

Kate J. Howell, Judith Kraiczy, Komal Nayak, +12

Gastroenterology

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

Judith Kraiczy, Komal Nayak, Kate J. Howell, +15

Gut

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

Brandon T. Wesley, Alexander Ross, Daniele Muraro, +29

Nature Cell Biology

Cell LineageHuman CellHepatic DisordersDevelopmental BiologyHepatology +10

Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids

Casey A. Rimland, Samantha Grace Tilson, Carola Maria Morell, +21

Hepatology

Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease

Judith Kraiczy, Komal Nayak, Alexander Ross, +7

Mucosal Immunology

Epigenetic ChangeGeneticsDna MethylationImmunologyGastroenterology +15

Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche

Judith Kraiczy, Neil McCarthy, Ermanno Malagola, +6

Cell stem cell

Cell LineageDevelopmental BiologySignal TransductionSignaling PathwayMedicine +6

SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

Wei Yong Gu, Hua Wang, Xiaofeng Huang, +22

Cell stem cell

Ileum-colon ConversionDevelopmental BiologyColorectal CancerStem Cell ResearchGut Barrier +3

Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis

Marco Gasparetto, Felicity Payne, Komal Nayak, +14

Gastroenterology

InflammationAutoimmune DiseaseDna Methylation PatternsMedicineT-regulatory Cell +10

Matrix-Assisted Transplantation of Functional Beige Adipose Tissue

Kevin M. Tharp, Amit K. Jha, Judith Kraiczy, +6

Diabetes

Interleukin-22 promotes phagolysosomal fusion to induce protection against <i>Salmonella enterica</i> Typhimurium in human epithelial cells

Jessica L. Forbester, Emily A. Lees, David Goulding, +13

Proceedings of the National Academy of Sciences