Concepedia

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

Judith Kraiczy, Komal Nayak, Kate J. Howell, Alexander Ross, Jessica L. Forbester, Camilla Salvestrini, Roxana C. Mustata, Sally Perkins, Amanda Andersson-Rolf, Esther Leenen,

Gut · 2017 · 185 citations · 36 references

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Abstract

Our study demonstrates striking similarities of epigenetic signatures in mucosa-derived IEOs with matching primary epithelium. Moreover, these results suggest that intestinal stem cell-intrinsic DNA methylation patterns establish and maintain regional gut specification and are involved in early epithelial development and disease.

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