Chenchang Li

Structure-Based Discovery and Optimization of Benzo[<i>d</i>]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)

Maofeng Zhang, Yan Zhang, Ming Song et al. · Journal of Medicinal Chemistry · 2018 · 60 citations · Full text

Discovery and optimization of 1-(1 H -indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer

Qiuping Xiang, Chao Wang, Yan Zhang et al. · European Journal of Medicinal Chemistry · 2018 · 59 citations · Full text

Medicinal Chemistry, Medicine, Cbp/ep300 Bromodomain Inhibitors +10

Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer

Lingjiao Zou, Qiuping Xiang, Xiaoqian Xue et al. · Acta Pharmacologica Sinica · 2019 · 47 citations · Full text

Molecular Pharmacology, Urology, Oncology +8

Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer

Yan Zhang, Xishan Wu, Xiaoqian Xue et al. · Journal of Medicinal Chemistry · 2019 · 38 citations · Full text

Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer

Xiaoqian Xue, Yan Zhang, Chao Wang et al. · European Journal of Medicinal Chemistry · 2018 · 27 citations · Full text

Medicinal Chemistry, Urology, Oncology +11