Yan Zhang

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

Junjian Wang, June X. Zou, Xiaoqian Xue et al. · Nature Medicine · 2016 · 196 citations · Full text

Urology, Ror-γ Drives, Medicine +7

Discovery and Optimization of 3-(2-(Pyrazolo[1,5-<i>a</i>]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors

Mingshan Gao, Lei Duan, Jinfeng Luo et al. · Journal of Medicinal Chemistry · 2013 · 154 citations · Full text

Drug Target, Chemoprevention Strategy, Pharmacotherapy +19

Discovery of Benzo[<i>cd</i>]indol-2(1<i>H</i>)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation

Xiaoqian Xue, Yan Zhang, Zhaoxuan Liu et al. · Journal of Medicinal Chemistry · 2016 · 82 citations · Full text

Drug Target, Bet Bromodomain Inhibitors, Chemical Biology +18

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

Lijie Peng, Zhensheng Zhang, Chong Lei et al. · ACS Medicinal Chemistry Letters · 2019 · 68 citations · Full text

Structure-Based Discovery and Optimization of Benzo[<i>d</i>]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)

Maofeng Zhang, Yan Zhang, Ming Song et al. · Journal of Medicinal Chemistry · 2018 · 60 citations · Full text