Theresa Johnson

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Christina Schindler, Hannah M. Baumann, Andreas Blum et al. · Journal of Chemical Information and Modeling · 2020 · 292 citations

Ability of Bruton’s Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling

Andrew T. Bender, A.S. Gardberg, Albertina Pereira et al. · Molecular Pharmacology · 2017 · 176 citations

Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases

Richard D. Caldwell, Hui Qiu, Ben Askew et al. · Journal of Medicinal Chemistry · 2019 · 136 citations · Full text

Novel Therapy, Medicine, Tyrosine Kinase +14

Structure of the Catalytic Domain of Human Polo-like Kinase 1^,

Michael Kothe, Darcy Kohls, Simon Low et al. · Biochemistry · 2007 · 123 citations

Catalytic Domain, Molecular Biology, Chemical Biology +19

Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity

Jaromir Vlach, Andrew T. Bender, Melinda Przetak et al. · Journal of Pharmacology and Experimental Therapeutics · 2020 · 79 citations · Full text