A quantitative analysis of kinase inhibitor selectivity

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Nature Biotechnology

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Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

Brian L. Hodous, Stephanie Geuns-Meyer, Paul E. Hughes, +25

Journal of Medicinal Chemistry

Molecular BiologyPharmacotherapyChemical BiologyTumor AngiogenesisTumor Biology +19

Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor β In Vivo

Malin Lindborg, Eliane Cortez, Ingmarie Höidén‐Guthenberg, +8

Journal of Molecular Biology

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Biochemical Characterization of the O-Linked Glycosylation Pathway in <i>Neisseria gonorrhoeae</i> Responsible for Biosynthesis of Protein Glycans Containing <i>N</i>,<i>N</i>′-Diacetylbacillosamine

Meredith D. Hartley, Michael J. Morrison, Finn Erik, +3

Biochemistry

Bioorganic ChemistryGlycobiologyPgl EnzymesPolysaccharideGlycoproteomics +17

Novel 2,3-Dihydro-1,4-Benzoxazines as Potent and Orally Bioavailable Inhibitors of Tumor-Driven Angiogenesis

Daniel S. La, Julie Belzile, James Bready, +21

Journal of Medicinal Chemistry

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Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck:  Synthesis, SAR, and in Vivo Antiinflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes, +42

Journal of Medicinal Chemistry

ImmunologyPharmacotherapyImmunotherapyChemical BiologyPharmaceutical Chemistry +16

Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor

Victor J. Cee, Laurie B. Schenkel, Brian L. Hodous, +28

Journal of Medicinal Chemistry

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Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors

Brian L. Hodous, Stephanie Geuns-Meyer, Paul E. Hughes, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)EngineeringNatural SciencesStructural Analysis +8

Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase

Victor J. Cee, Brian K. Albrecht, Stephanie Geuns-Meyer, +24

Journal of Medicinal Chemistry

Identification of a peptide inhibitor for the histone methyltransferase WHSC1

Michael J. Morrison, P. Ann Boriack‐Sjodin, Kerren K. Swinger, +11

PLoS ONE

Histone ModificationsEpigenetic ChangeWhsc1 InhibitorMolecular BiologyChemical Biology +15