Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

Lars Kuepfer, Christoph Niederalt, Thomas Wendl, +5

CPT Pharmacometrics & Systems Pharmacology

EngineeringModeling MethodPhysiologically-based Pharmacokinetic ModelingPharmacodynamic ModelingDrug Resistance +24

Characterization of chitosan thiolation and application to thiol quantification onto nanoparticle surface

Irene Bravo‐Osuna, Donato Teutonico, Silvia Arpicco, +2

International Journal of Pharmaceutics

NanoparticlesEngineeringNanomaterialsNanotechnologyChitosan Thiolation +4

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

Arne Schenk, Ahmed Ghallab, Ute Hofmann, +8

Scientific Reports

Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

Donato Teutonico, Flora T. Musuamba, Hugo Maas, +4

Pharmaceutical Research

Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits

Panteleimon D. Mavroudis, Helen E. Hermes, Donato Teutonico, +2

PLoS ONE

Environmental FatesIntense ReviewPhysiologically-based Pharmacokinetic ModelingPharmacodynamic ModelingDrug Resistance +17

Application of machine learning in combination with mechanistic modeling to predict plasma exposure of small molecules

Panteleimon D. Mavroudis, Donato Teutonico, Alexandra Abós, +1

Frontiers in Systems Biology

Machine learning framework to predict pharmacokinetic profile of small molecule drugs based on chemical structure

Nikhil Pillai, Alexandra Abós, Donato Teutonico, +1

Clinical and Translational Science

Physiologically based pharmacokinetic modeling of tacrolimus for <scp>food–drug</scp> and <scp>CYP3A drug–drug–gene</scp> interaction predictions

Helena Leonie Hanae Loer, Denise Feick, Simeon Rüdesheim, +8

CPT Pharmacometrics & Systems Pharmacology

Food IntakePharmacotherapySystem PharmacologyPhysiologically-based Pharmacokinetic ModelingPharmacodynamic Modeling +15

Prediction of Disease Progression, Treatment Response and Dropout in Chronic Obstructive Pulmonary Disease (COPD)

Flora T. Musuamba, Donato Teutonico, Hugo Maas, +4

Pharmaceutical Research

Physiologically‐based pharmacokinetic modeling of quinidine to establish a <scp>CYP3A4</scp>, P‐gp, and <scp>CYP2D6 drug–drug–gene</scp> interaction network

Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, +9

CPT Pharmacometrics & Systems Pharmacology

Molecular PharmacologyMedicinal ChemistryPharmacokinetic ModelingBiochemistryMedicine +11