Sublethal necroptosis signaling promotes inflammation and liver cancer

Mihael Vucur, Ahmed Ghallab, Anne T. Schneider, +59

Immunity

Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity

Sina Köppert, Andrea Büscher, Anne Babler, +6

Frontiers in Immunology

Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling

Kai Markus Schneider, Lena Susanna Candels, Johannes R. Hov, +23

Nature Metabolism

DysbiosisImmunologyGastroenterologyPathologyCholangiopathies +15

Integrated metabolic spatial‐temporal model for the prediction of ammonia detoxification during liver damage and regeneration

Freimut Schliess, Stefan Hoehme, Sebastian Henkel, +10

Hepatology

A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation

Christoph Thiel, Sebastian Schneckener, Ahmed Ghallab, +6

Journal of Pharmaceutical Sciences

Physiologically Based PharmacokineticsPharmacokinetic ModelingHealth SciencesPharmacological StudyMedicine +8

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

Ahmed Ghallab, Géraldine Cellière, Sebastian Henkel, +14

Journal of Hepatology

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Wiebke Albrecht, Franziska Kappenberg, Tim Brecklinghaus, +45

Archives of Toxicology

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

Patrício Godoy, Agata Widera, Wolfgang Schmidt‐Heck, +29

Archives of Toxicology

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, +19

Hepatology

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury

Kai Markus Schneider, Carsten Elfers, Ahmed Ghallab, +21

Cellular and Molecular Gastroenterology and Hepatology