Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus

Sabrina Prudente, Prapaporn Jungtrakoon, Antonella Marucci, +21

The American Journal of Human Genetics

Genetic DisorderGeneticsDiabetesGenetic EpidemiologyDisease Gene Identification +2

Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

Dario F. De Jesus, Kazuki Orime, Dorota Kamińska, +14

Journal of Clinical Investigation

Human duct cells contribute to β cell compensation in insulin resistance

Ercument Dirice, Dario F. De Jesus, Sevim Kahraman, +7

JCI Insight

Cell CompensationCellular PhysiologyInsulin SignalingMetabolic SyndromeMetabolic Signaling +17

Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8

Sevim Kahraman, Ercument Dirice, Giorgio Basile, +11

Nature Metabolism

Developmental BiologySignal TransductionSignaling PathwayEndocrine MechanismCellular Regulatory Mechanism +7

Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes

Ercument Dirice, Sevim Kahraman, Dario F. De Jesus, +21

Nature Metabolism

InflammationType 1Immune Cell InvasionDiabetes EpidemiologyDiabetes +5

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, +18

Nature Cell Biology

InflammationType 1Immune Cell DevelopmentRedox RegulationDiabetes +12

Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets

Giorgio Basile, Sevim Kahraman, Ercument Dirice, +3

Genome Medicine

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway

Jun Shirakawa, Kazuki Tajima, Tomoko Okuyama, +8

Diabetologia

Beta Cell ProliferationSignal TransductionSignaling PathwayInsulin Receptor-Growth Hormone +8

E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance

Jun Shirakawa, Yu Togashi, Giorgio Basile, +15

Cell Reports

Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways

Giorgio Basile, Amedeo Vetere, Jiang Hu, +15

Cell Metabolism

Molecular PhysiologySignal TransductionCell CommunicationPar2 PathwaysSignaling Pathway +8