Shingo Eikawa

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

Shingo Eikawa, Mikako Nishida, Shusaku Mizukami et al. · Proceedings of the National Academy of Sciences · 2015 · 535 citations · Full text

Life Sciences, Immunology, Oncology +16

Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Yuki Kunisada, Shingo Eikawa, Nahoko Tomonobu et al. · EBioMedicine · 2017 · 150 citations · Full text

Life Sciences, Immunology, Oncology +17

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

Takenori Uehara, Shingo Eikawa, Mikako Nishida et al. · International Immunology · 2018 · 118 citations · Full text

Life Sciences, Immunology, Oncology +17

Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation

Masahiro Takahara, Akinobu Takaki, Sakiko Hiraoka et al. · Scientific Reports · 2019 · 79 citations · Full text

Life Sciences, Immunology, Pathology +17

Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6– and IL-8–Expressing Tumors through Predominant Induction of CXCR1 by IL-6

Shingo Eikawa, Yoshihiro Ohue, Kenta Kitaoka et al. · The Journal of Immunology · 2010 · 66 citations · Full text

Life Sciences, Immunology, Oncology +17