Immune-mediated antitumor effect by type 2 diabetes drug, metformin

Shingo Eikawa, Mikako Nishida, Shusaku Mizukami, +3

Proceedings of the National Academy of Sciences

ImmunologyImmune RegulationImmunoeditingImmunotherapeuticsImmune Cell Therapy +25

Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Yuki Kunisada, Shingo Eikawa, Nahoko Tomonobu, +7

EBioMedicine

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

Takenori Uehara, Shingo Eikawa, Mikako Nishida, +6

International Immunology

Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation

Masahiro Takahara, Akinobu Takaki, Sakiko Hiraoka, +16

Scientific Reports

Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6– and IL-8–Expressing Tumors through Predominant Induction of CXCR1 by IL-6

Shingo Eikawa, Yoshihiro Ohue, Kenta Kitaoka, +4

The Journal of Immunology

Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

Ichiro Nojima, Shingo Eikawa, Nahoko Tomonobu, +11

Scientific Reports

Increase in Activated Treg in TIL in Lung Cancer and In Vitro Depletion of Treg by ADCC Using an Antihuman CCR4 mAb (KM2760)

Koji Kurose, Yoshihiro Ohue, Eiichi Sato, +7

Journal of Thoracic Oncology

Cancer ImmunosurveillanceOncogenic AgentImmunologyRegulatory T CellsActivated Treg +7

Spontaneous antibody, and CD4 and CD8 T‐cell responses against XAGE‐1b (GAGED2a) in non‐small cell lung cancer patients

Yoshihiro Ohue, Shingo Eikawa, N Okazaki, +7

International Journal of Cancer

ImmunologyPathologyAntigen ProcessingCd4 T Cell ResponsesImmunotherapy +16

Vaccination With NY-ESO-1 Overlapping Peptides Mixed With Picibanil OK-432 and Montanide ISA-51 in Patients With Cancers Expressing the NY-ESO-1 Antigen

Hisashi Wada, Midori Isobe, Kazuhiro Kakimi, +19

Journal of Immunotherapy

Induction of CD8 T‐cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20‐mer NY‐ESO‐1f (NY‐ESO‐1 91‐110) peptide

Shingo Eikawa, Kazuhiro Kakimi, Midori Isobe, +9

International Journal of Cancer

HistocompatibilityAdaptive Immune SystemHla ImmunogeneticsImmunologyImmunoediting +24