<i>N</i>-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. <i>N</i>-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

Raj N. Misra, Hai‐Yun Xiao, Kyoung S. Kim, +23

Journal of Medicinal Chemistry

Chemoprevention StrategyImmunologyPharmacotherapyCdk2/cyce IcPharmaceutical Chemistry +17

Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2:  Synthesis, X-ray Crystallographic Analysis, and Biological Activities

Kyoung Soon Kim, S. David Kimball, Raj N. Misra, +27

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetCdk2 ProteinCompound 14Heterocycle Chemistry +18

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors

Ashvinikumar V. Gavai, Claude Quesnelle, Derek Norris, +35

ACS Medicinal Chemistry Letters

Solid TumorsPharmacotherapyTumor BiologyMyeloid NeoplasiaHematological Malignancy +16

1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues

Raj N. Misra, Hai-yun Xiao, David B. Rawlins, +7

Bioorganic & Medicinal Chemistry Letters

Cyclin-dependent KinasesHeterocyclicBiochemistryMedicineAnti-cancer Agent +2

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists

Mark Salvati, Aaron Balog, Weifang Shan, +11

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryAndrogen Receptor AntagonistsMedicinal ChemistryHeterocyclicNatural Sciences +6

Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer

Ricardo M. Attar, Maria Jure–Kunkel, Aaron Balog, +15

Cancer Research

Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies

Patrick J. McEnaney, Kelly Fitzgerald, Andrew X. Zhang, +5

Journal of the American Chemical Society

NanotherapeuticsPeptide ScienceImmunotherapeuticsImmunotherapyIntermediate Size +24

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists

Mark Salvati, Aaron Balog, Weifang Shan, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNovel SeriesBiochemistryMedicineNatural Sciences +8

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists

Aaron Balog, Mark Salvati, Weifang Shan, +12

Bioorganic & Medicinal Chemistry Letters

Androgen Receptor AntagonistsMedicinal ChemistryHeterocyclicBiochemistryMedicine +8

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer

Aaron Balog, Richard Rampulla, Greg S. Martin, +19

ACS Medicinal Chemistry Letters

Medicinal ChemistryUrologyFunctional AntagonistEndocrine-related CancerFunctional Selectivity +10