<i>N</i>-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. <i>N</i>-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

Raj N. Misra, Hai‐Yun Xiao, Kyoung S. Kim, +23

Journal of Medicinal Chemistry

Chemoprevention StrategyImmunologyPharmacotherapyCdk2/cyce IcPharmaceutical Chemistry +17

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial

Brian Zambrowicz, J Freiman, Phil Brown, +14

Clinical Pharmacology & Therapeutics

The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor

Paul A. Wender, Neil F. Badham, Simon P. Conway, +19

Journal of the American Chemical Society

BiologyPinene PathEngineeringDonut IconNatural Sciences +10

Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2:  Synthesis, X-ray Crystallographic Analysis, and Biological Activities

Kyoung Soon Kim, S. David Kimball, Raj N. Misra, +27

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetCdk2 ProteinCompound 14Heterocycle Chemistry +18

Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma

Bryce A. Harrison, N. Andrew Whitlock, Michael Voronkov, +22

Journal of Medicinal Chemistry

HypertensionOcular DiseaseOphthalmologyIntraocular PressureMedicine +12

Novel <scp>l</scp>-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes

Nicole C. Goodwin, Ross Mabon, Bryce A. Harrison, +14

Journal of Medicinal Chemistry

Medicinal ChemistryDiabetes ManagementBiochemistryNovel O-xyloside 7CMedicine +11

1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues

Raj N. Misra, Hai-yun Xiao, David B. Rawlins, +7

Bioorganic & Medicinal Chemistry Letters

Cyclin-dependent KinasesHeterocyclicBiochemistryMedicineAnti-cancer Agent +2

Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation

Nicole C. Goodwin, Giovanni Cianchetta, Hugh A. Burgoon, +7

ACS Medicinal Chemistry Letters

Drug TargetMolecular BiologyLim Kinase 2Chemical BiologyType Iii Inhibitor +21

Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes

Nicole C. Goodwin, Zhi‐Ming Ding, Bryce A. Harrison, +16

Journal of Medicinal Chemistry

Medicinal ChemistryTranslational MedicineDiabetes ManagementBiochemistrySodium-dependent Glucose Cotransporters +13

Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

Bryce A. Harrison, Zheng Y. Almstead, Hugh A. Burgoon, +18

ACS Medicinal Chemistry Letters

HypertensionOcular DiseaseOphthalmologyIntraocular PressureMedicine +12