Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

Kambez H. Benam, Rémi Villenave, Carolina Lucchesi, +10

Nature Methods

AsthmaInflammationDrug ResponsesEngineeringInflammatory Lung Disease +10

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

Longlong Si, Haiqing Bai, Melissa Rodas, +35

Nature Biomedical Engineering

Viral DiagnosticsRapid IdentificationMedicineCandidate Antiviral TherapeuticsAntiviral Response +5

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

Kambez H. Benam, Richard Novák, Janna Nawroth, +8

Cell Systems

AsthmaHuman Airway ResponsesEngineeringVentilationMatched-comparative Modeling +5

Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection

Wai Ling Kok, Laura Denney, Kambez H. Benam, +4

Journal of Leukocyte Biology

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza

Suzanne Cole, Jake Dunning, Wai Ling Kok, +18

JCI Insight

Human Lung Small Airway-on-a-Chip Protocol

Kambez H. Benam, M Mazur, Youngjae Choe, +3

Methods in molecular biology

AsthmaPulmonary CareLung MechanicsPulmonary MedicineBiomedical Engineering +2

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

Longlong Si, Haiqing Bai, Melissa Rodas, +29

EngineeringInflammatory Lung DiseaseViral DiagnosticsSynthetic VirologyViral Pathogenesis +20

Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips

Kambez H. Benam, Richard Novák, Thomas C. Ferrante, +2

Nature Protocols

EngineeringMicrofabricationBiomimetic Smoking RobotMicrofluidic Organ ChipsLab-on-a-chip +7

Discovery of influenza drug resistance mutations and host therapeutic targets using a human airway chip

Longlong Si, Rachelle Prantil‐Baun, Kambez H. Benam, +4

Drug TargetOrgan Chip ModelSynthetic VirologyImmunologyMolecular Biology +15

Exploring new technologies in biomedical research

Kambez H. Benam, Siobhan Gilchrist, André Kleensang, +3

Drug Discovery Today

Preclinical TherapeuticsNew TechnologiesEngineeringBiomedical EthicBiomedical Engineering +20