<scp>GSDMD</scp> membrane pore formation constitutes the mechanism of pyroptotic cell death

Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, +7

The EMBO Journal

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, +3

Science

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

Petr Brož, Jakob von Moltke, Jonathan Jones, +2

Cell Host & Microbe

InflammationDifferential RequirementCytokineAutoimmune DiseaseAutoantibody Production +10

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Kaiwen Chen, Mercedes Monteleone, Dave Boucher, +7

Science Immunology

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against<i>Salmonella</i>

Petr Brož, Kim Newton, Mohamed Lamkanfi, +3

The Journal of Experimental Medicine

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

Petr Brož, Thomas Ruby, Kamila Belhocine, +4

Nature

InflammationCaspase-11 Increases SusceptibilityTyphoid FeverVirulence FactorPathogenesis +6

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Christina J. Groß, Ritu Mishra, Katharina S. Schneider, +24

Immunity

InflammationSignal TransductionSignaling PathwayMitochondrial FunctionNatural Sciences +9

Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K ⁺ efflux

Sebastian Rühl, Petr Brož

European Journal of Immunology

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Étienne Meunier, Mathias S. Dick, Roland F. Dreier, +9

Nature

InflammationSignal TransductionPathogenesisImmunologyEndocytic Pathway +9

Absent in melanoma 2 is required for innate immune recognition of <i>Francisella tularensis</i>

Jonathan Jones, Nobuhiko Kayagaki, Petr Brož, +9

Proceedings of the National Academy of Sciences