Molecular Analysis of Hereditary Nonpolyposis Colorectal Cancer in the United States: High Mutation Detection Rate among Clinically Selected Families and Characterization of an American Founder Genomic Deletion of the MSH2 Gene

Anja Wagner, Alicia Barrows, Juul Wijnen, +19

The American Journal of Human Genetics

OncologySomatic VariantMedicineGeneticsMolecular Analysis +9

Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway

Kim U. Birkenkamp, Marjan Geugien, Hein Schepers, +3

Leukemia

Transcriptional RegulationSignal TransductionRas/pi3-k/pkb-dependent PathwaySignaling PathwayCell Regulation +8

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

Vincent van den Boom, Henny Maat, Marjan Geugien, +12

Cell Reports

Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts

KU Birkenkamp, Marjan Geugien, H.H. Lemmink, +2

Leukemia

Hematological MalignancyTranscriptional RegulationSignal TransductionCell RegulationMixed-phenotype Acute Leukemia +7

SomaticApc mutations are selected upon their capacity to inactivate the ?-catenin downregulating activity

Ron Smits, Nandy Hofland, Winfried Edelmann, +7

Genes Chromosomes and Cancer

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Ayşegül Erdem, Silvia Marín, Diego A. Pereira‐Martins, +12

Nature Communications

HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun

Hein Schepers, Marjan Geugien, Marco van der Toorn, +4

Experimental Hematology

CytokineSignaling PathwayCell RegulationApoptosisImmunology +7

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

Ayşegül Erdem, Silvia Marín, Diego A. Pereira‐Martins, +11

Nature Communications

Constitutive cytoplasmic localization of p21Waf1/Cip1 affects the apoptotic process in monocytic leukaemia

Hein Schepers, Marjan Geugien, Bart J. L. Eggen, +1

Leukemia

Hematological MalignancyMixed-phenotype Acute LeukemiaMyeloid NeoplasiaPathologyCell Death +6

Dietary methionine starvation impairs acute myeloid leukemia progression

Alan Cunningham, Ayşegül Erdem, Islam Alshamleh, +21

Blood