Jurgen Joossens

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

Koen Jansen, Leen Heirbaut, Robert Verkerk et al. · Journal of Medicinal Chemistry · 2014 · 264 citations · Full text

Structure–activity Relationship, Drug Target, Cellular Pharmacology +17

Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold

Koen Jansen, Leen Heirbaut, Jonathan D. Cheng et al. · ACS Medicinal Chemistry Letters · 2013 · 246 citations · Full text

Bioorganic Chemistry, Selective Inhibitors, Chemical Biology +17

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Sam Hofmans, Tom Vanden Berghe, Lars Devisscher et al. · Journal of Medicinal Chemistry · 2015 · 131 citations

Glutathione Peroxidase 4, Lipid Peroxidation, Chemical Biology +16

Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile)

Inger Brandt, Jurgen Joossens, Xin Chen et al. · Biochemical Pharmacology · 2005 · 120 citations

Peptide Truncation, Medicinal Chemistry, Biochemistry +10

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Sofie Martens, Manhyung Jeong, Wulf Tonnus et al. · Cell Death and Disease · 2017 · 85 citations · Full text