Sam Hofmans

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

Lars Devisscher, Samya Van Coillie, Sam Hofmans et al. · Journal of Medicinal Chemistry · 2018 · 160 citations

Lipid Peroxidation, Pharmacotherapy, Drug-like Ferroptosis Inhibitors +17

Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties

Sam Hofmans, Tom Vanden Berghe, Lars Devisscher et al. · Journal of Medicinal Chemistry · 2015 · 131 citations

Glutathione Peroxidase 4, Lipid Peroxidation, Chemical Biology +16

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Sofie Martens, Manhyung Jeong, Wulf Tonnus et al. · Cell Death and Disease · 2017 · 85 citations · Full text

RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

Sofie Martens, Vera Goossens, Lars Devisscher et al. · Cell Death and Disease · 2018 · 58 citations · Full text

Tozasertib Analogues as Inhibitors of Necroptotic Cell Death

Sam Hofmans, Lars Devisscher, Sofie Martens et al. · Journal of Medicinal Chemistry · 2018 · 47 citations · Full text

Inflammation, Tumor Necrosis Factor, Anti-inflammatory +15