An automated microseed matrix-screening method for protein crystallization

A. D’Arcy, Frédéric Villard, M. Marsh

Acta Crystallographica Section D Biological Crystallography

EngineeringBiomolecular Structure PredictionProtein Phase SeparationProtein CrystallizationProtein Purification +14

MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans

Alexander W. Koch, Nikolaus Schiering, Samu Melkko, +28

Blood

Structural Determinants of MALT1 Protease Activity

Christian Wiesmann, Lukas Leder, Jutta Blank, +12

Journal of Molecular Biology

Lymphocyte DevelopmentImmune RegulationProteasomeMolecular BiologyImmunology +23

Structure of neprilysin in complex with the active metabolite of sacubitril

Nikolaus Schiering, A. D’Arcy, Frédéric Villard, +7

Scientific Reports

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

Jean Quancard, Théo Klein, Shan‐Yu Fung, +17

Nature Chemical Biology

Autoimmune DiseaseImmunodeficient PatientImmunodeficienciesImmunologyPathology +9

A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target

Nikolaus Schiering, A. D’Arcy, Frédéric Villard, +9

Proceedings of the National Academy of Sciences

Viral ReplicationProtein AssemblyHepatitis C VirusMolecular BiologyViral Structural Protein +17

Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors

Fedir Bokhovchuk, Yannick Mesrouze, Clara Delaunay, +10

Protein Science

Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

Juraj Velcicky, Rainer Wilcken, Simona Cotesta, +14

Journal of Medicinal Chemistry

Pharmaceutical ScienceDrug TargetNovel Sucnr1 InhibitorsPharmacotherapyOral Exposure +17

Purification and crystallization of dengue and West Nile virus NS2B–NS3 complexes

A. D’Arcy, Maxime Chaillet, Nikolaus Schiering, +4

Acta Crystallographica Section F Structural Biology and Crystallization Communications

High ResolutionBiomolecular Structure PredictionMolecular BiologyLead IdentificationChemistry +14

Hyperglycemia Interacts with Ischemia in a Synergistic Way on Wound Repair and Myofibroblast Differentiation

Mickaël Tobalem, Dominik André‐Lévigne, Ali Modarressi, +4

Plastic & Reconstructive Surgery Global Open