William M. Barker

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of<i>N</i>,<i>N</i>-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Bertrand Le Bourdonnec, Rolf T. Windh, Christopher W. Ajello et al. · Journal of Medicinal Chemistry · 2008 · 90 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of<i>N</i>,<i>N</i>-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Bertrand Le Bourdonnec, Rolf T. Windh, Lara K. Leister et al. · Journal of Medicinal Chemistry · 2009 · 85 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Annulation of Primary Amines to Piperazines and Diazaspirocycles Utilizing α-Methyl Benzyl Resin

Calum Macleod, Blanca Martínez‐Teipel, William M. Barker et al. · Journal of Combinatorial Chemistry · 2005 · 32 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

Solid/Solution‐Phase Annulation Reagents: Single‐Step Synthesis of Cyclic Amine Derivatives

Roland E. Dolle, Calum Macleod, Blanca Martínez‐Teipel et al. · Angewandte Chemie International Edition · 2005 · 26 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Azepinone as a conformational constraint in the design of κ-opioid receptor agonists

Paul A. Tuthill, Pamela R. Seida, William M. Barker et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 21 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14