Andrew B. Kleist

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

Ryan T. Strachan, Jin‐Peng Sun, David H. Rominger et al. · Journal of Biological Chemistry · 2014 · 130 citations · Full text

Biased Agonism, Immunology, Molecular Biology +20

Evolution of fold switching in a metamorphic protein

Acacia F. Dishman, Robert C. Tyler, Jamie Fox et al. · Science · 2020 · 110 citations · Full text

Different Folds, Protein Assembly, Protein Folding +11

Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor

Dahlia R. Weiss, Seungkirl Ahn, Maria F. Sassano et al. · ACS Chemical Biology · 2013 · 109 citations · Full text

Drug Target, Quantitative Pharmacology, Peptide Science +21

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

Joshua J. Ziarek, Andrew B. Kleist, Nir London et al. · Science Signaling · 2017 · 95 citations

Chemokine Biology, Engineering, Immunology +24

Different contributions of chemokine N‐terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3

Martyna Szpakowska, Amanda M. Nevins, Max Meyrath et al. · British Journal of Pharmacology · 2017 · 66 citations · Full text