Jessica McManus

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule

Gejing Deng, Junqing Shen, Ming Yin et al. · Journal of Biological Chemistry · 2014 · 137 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Maysoun Shomali, Jane Cheng, Fangxian Sun et al. · Molecular Cancer Therapeutics · 2020 · 67 citations · Full text

Medicine, Oncology, Pharmacology +15

Relaxation of the guinea-pig tracheal chain preparation by<i>N</i>6, 2‘-<i>O</i>-dibutyryl 3’,5‘-cyclic adenosine monophosphate

Peter F. Moore, Louis C. Iorio, Jessica McManus · Journal of Pharmacy and Pharmacology · 1968 · 66 citations

Life Sciences, Biochemistry, Pharmacology +10

Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches

Qiang Gao, I. Mechin, Nayantara Kothari et al. · Journal of Biological Chemistry · 2013 · 31 citations · Full text

Pharmacy, Molecular Biology, Oncology +12

A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities

Jessica McManus, Timothy He, Julie-Ann Gavigan et al. · SLAS DISCOVERY · 2018 · 15 citations · Full text

Medicine, Oncology, Pharmacology +16