Stephen T. Worland

Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein

David A. Matthews, Ward W. Smith, Rose Ann Ferre et al. · Cell · 1994 · 356 citations

Virus Structure, Viral Replication, Protein Folding +11

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

David A. Matthews, Peter S. Dragovich, S. E. Webber et al. · Proceedings of the National Academy of Sciences · 1999 · 316 citations

Translation control of the immune checkpoint in cancer and its therapeutic targeting

Yichen Xu, Mauro Poggio, Hyun Yong Jin et al. · Nature Medicine · 2019 · 256 citations · Full text

Immune Checkpoint, Tumor Biology, Cancer Immunosurveillance +12

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

Stephen T. Worland, J C Wang · Journal of Biological Chemistry · 1989 · 251 citations · Full text

Gene Top2 Downstream, Molecular Biology, Molecular Genetics +16

In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease

Amy K. Patick, Susan L. Binford, M. A. Brothers et al. · Antimicrobial Agents and Chemotherapy · 1999 · 223 citations · Full text