Resolving medulloblastoma cellular architecture by single-cell genomics

Volker Hovestadt, Kyle Smith, Laure Bihannic, +48

Nature

Tumor HeterogeneityMedicineSingle Cell SequencingSingle-cell BiologySingle-cell Genomics +3

SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins

Mi-Jeong Park, Ren Sheng, Antonina Silkov, +21

Molecular Cell

Sh2 Domains ServeSignal TransductionSignaling PathwayNatural SciencesReceptor Tyrosine Kinase +5

Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

Scott Newman, Liying Fan, Allison Pribnow, +20

Nature Medicine

Other MelanomasTumor BiologyClinical GenomeMedicineMelanoma +8

Structural Alignment of Protein–DNA Interfaces: Insights into the Determinants of Binding Specificity

Trevor Siggers, Antonina Silkov, Barry Honig

Journal of Molecular Biology

Structural AlignmentProtein–dna InterfacesBiochemistryStructural BioinformaticsNatural Sciences +4

Genome-wide Functional Annotation of Dual-Specificity Protein- and Lipid-Binding Modules that Regulate Protein Interactions

Yong Chen, Ren Sheng, Morten Källberg, +8

Molecular Cell

BioinformaticsSystems BiologyInteractomicsGenome-wide Functional AnnotationMedicine +11

An Ankyrin Repeat Domain of AKR2 Drives Chloroplast Targeting through Coincident Binding of Two Chloroplast Lipids

Dae Heon Kim, Mi-Jeong Park, G.H. Gwon, +11

Developmental Cell

Proteinlipid InteractionCoincident BindingBiochemistryNatural SciencesMolecular Biology +2

Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain

Ren Sheng, Da-Jung Jung, Antonina Silkov, +14

Journal of Biological Chemistry

Specific Interaction of TAFII105 with OCA-B Is Involved in Activation of Octamer-dependent Transcription

Orit Wolstein, Antonina Silkov, Merav Revach, +1

Journal of Biological Chemistry

p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase

Douglas Barrows, Sarah Schoenfeld, Cindy Hodakoski, +7

Journal of Biological Chemistry

Signal TransductionSignaling PathwayCell RegulationMedicineNatural Sciences +8

Genome-wide Structural Analysis Reveals Novel Membrane Binding Properties of AP180 N-terminal Homology (ANTH) Domains

Antonina Silkov, Youngdae Yoon, Hunjoong Lee, +5

Journal of Biological Chemistry