Rogier W. Rooswinkel

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

Gabriel Ichim, Jonathan Lopez, Shafiq U. Ahmed et al. · Molecular Cell · 2015 · 469 citations · Full text

Life Sciences, Cell Biology, Oncology +13

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity

Rogier W. Rooswinkel, Bert van de Kooij, Evert de Vries et al. · Blood · 2014 · 110 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

Absence of Both Cytochrome <i>P</i> 450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

Robert A.B. van Waterschoot, Jurjen S. Lagas, Els Wagenaar et al. · Cancer Research · 2009 · 97 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Markus Haake, Beatrice Haack, Tina Schäfer et al. · Nature Communications · 2023 · 91 citations · Full text

Medicine, Immunology, Oncology +17

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B

Rogier W. Rooswinkel, Bert van de Kooij, Marcel Verheij et al. · Cell Death and Disease · 2012 · 85 citations · Full text

Medicine, Oncology, Pharmacology +17