The Identification of Indacaterol as an Ultralong-Acting Inhaled β₂-Adrenoceptor Agonist

François Baur, David T. Beattie, David Beer, +31

Journal of Medicinal Chemistry

AsthmaMolecular PharmacologyTargeted Intermediate PotencyPulmonary CirculationVivo Profiling +9

Investigating the molecular mechanisms through which <scp>FTY</scp>720‐<scp>P</scp> causes persistent <scp>S1P₁</scp> receptor internalization

David A. Sykes, Darren Riddy, Craig Stamp, +9

British Journal of Pharmacology

Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy

David A. Sykes, Michelle Bradley, Darren Riddy, +8

Molecular Pharmacology

An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol

David T. Beattie, David Beer, Michelle Bradley, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryβ2-Adrenoceptor Agonist IndacaterolMedicineMechanism Of Action +6

A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilators

David T. Beattie, Michelle Bradley, Andrew Brearley, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryRespiratory ToxicologyMedicinePulmonary Pharmacology +4

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists

David W. Porter, Michelle Bradley, Zarin Brown, +13

Bioorganic & Medicinal Chemistry Letters

Bioavailable PyrazoloMedicineRational Drug DesignMechanism Of ActionPharmacological Agent +6

The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists

David W. Porter, Michelle Bradley, Zarin Brown, +10

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineReceptor (Biochemistry)Pharmacological AgentPharmacotherapy +3

Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor

Elizabeth M. Rosethorne, Michelle Bradley, Karolina Gherbi, +7

Molecular Pharmacology

Functional desensitization of the <i>β</i>₂ adrenoceptor is not dependent on agonist efficacy

Elizabeth M. Rosethorne, Michelle Bradley, Toby Kent, +1

Pharmacology Research & Perspectives

QAW039, a slowly dissociating CRTh2 antagonist with potential for improved clinical efficacy

David A. Sykes, Michelle Bradley, Darren Riddy, +7

AsthmaCrth2 ReceptorInflammatory Lung DiseaseLung InflammationImmunology +15